Hydrazones derived from natural aldehydes: in vitro cytotoxic evaluation and in silico pharmacokinetic predictions

Introduction: Recent research has reported the cytotoxic potential of hydrazones against various strains cancer cells. Aim: To evaluate anticancer activity in vitro and pharmacokinetic profile six synthesized hydrazonic compounds, identified as vanillin 1-phthalazinylhydrazone (VAN-1); 2,4-dinitrophenylhydrazone (VAN-2); phenylhydrazone cinnamaldehyde (CIN-1); isonicotinoyl hydrazone (CIN-2); 1 phthalazinylhydrazone (CIN-3); 2,4 dinitrophenylhydrazone (CIN-4). Thecytotoxic was evaluated four Methodology: Thepharmacokinetic parameters absorption, distribution, metabolism, excretion, toxicity (ADME/T) were using PreADMET program. Results: Hydrazones derived from (CIN-1 CIN-2) showed high leukemic (HL-60) glioblastomas (SF-295) cell lines. The that, general, presented satisfactory characteristics ADME/T. In addition, it observed that CIN-2 most promising silico profile, showing intestinal desirable distribution related to plasma protein binding, adequate renal low toxicity. ADME/T CIN-1 compound highlighted its a antineoplastic agent with action CNS, more specifically glioblastomas.